To demonstrate the importance of our UCANR4A initiative, I would like to introduce Feyza to you. Feyza was born 1997 and meanwhile has become a young Lady. I got to know her during my Rheumatology Fellowship in Münster 2004. She suffered from sever vasculitis resulting in amputation of all toes and fingers and severe growth retardation. All diagnostic procedures that had been performed did ultimately not result in a diagnosis. Therapeutic immunosuppressive regimens including modern biologics (anti-Interleukin 1, anti-Interleukin 6, anti-TNF) die not stop the disease. Finally, in 2012 a whole genome sequencing was performed at the University clinic of Münster and at the National Institute of Health (NIH) in Washington in the group of Raphaela Goldbach-Manski. We found a mutation in a protein called STING, which regulates interferones that are important for the fight against viral infections. STING fires too strong in Feyza's body. Raphaela Goldbach-Manski identified other patients with similar mutations of STING and started a therapy with a (Jak-Stat) Inhibitor , that reduces the signals of the Interferon-pathways. As a result of this treatment, the inflammation in Feyza's Body is almost gone, she gained weight and height, supports our initiative and will soon start to study. Without whole Genome sequencing this success would not have been possible.